A new mathematical model for the heat shock response (bibtex)
by Petre, Ion, Mizera, Andrzej, Hyder, Claire L., Mikhailov, Andrey, Eriksson, John E., Sistonen, Lea and Back, Ralph-Johan
Abstract:
We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.
Reference:
A new mathematical model for the heat shock response (Petre, Ion, Mizera, Andrzej, Hyder, Claire L., Mikhailov, Andrey, Eriksson, John E., Sistonen, Lea and Back, Ralph-Johan), In Proceedings of COMPMOD 2008 (Ralph-Johan Back, Ion Petre, ed.), Turku Centre for Computer Science, volume 47, 2008.
Bibtex Entry:
@InProceedings{inp188,
author    = {Petre, Ion AND Mizera, Andrzej AND Hyder, Claire L. AND Mikhailov, Andrey AND Eriksson, John E. AND Sistonen, Lea AND Back, Ralph-Johan},
title     = {A new mathematical model for the heat shock response},
booktitle = {Proceedings of COMPMOD 2008},
year      = {2008},
editor    = {Ralph-Johan Back, Ion Petre},
volume    = {47},
series    = {General Publications},
pages     = {39-52},
publisher = {Turku Centre for Computer Science},
abstract  = {We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.},
keywords  = {Heat shock response, heat shock protein, heat shock factor, mathematical model, differential equations, model fit, sensitivity analysis},
pdf       = {pdfs/PMHMESB2008c.pdf},
}